Marcelo Bielsa’s side return to the field following a nine-day absence after a postponed fixture against Southampton and a free FA Cup weekend.
Meanwhile, under pressure Steve Bruce is in desperate need of a result with the Magpies currently 10 games without a win.
It’s a huge game for both teams in the context of the bottom end of the top-flight table.
Ahead of tonight’s game, we’ve decided to create a ‘combined XI’ – as decided by popular statistics site WhoScored.com, who have given an average rating to each player so far.
So, which of Bielsa’s players feature? Scroll and click through our gallery to see how the starting XI shapes up:
1. Karl Darlow - 6.93
The 30-year-old has been an ever-present for the Magpies in the Premier League this season as Martin Dubravka battled back from injury. WhoScored rating: 6.93. Photo: Alex Pantling
2. Luke Ayling - 6.95
Spent most of the season in central defence but is a right-back by trade. With Diego Llorente back fit, Ayling could soon be switched back to his favoured position. WhoScored rating: 6.95. Photo: Michael Regan
3. Liam Cooper - 7.06
The Leeds captain comfortably earns his spot. His WhoScored rating is bettered only by Patrick Bamford. WhoScored rating: 7.06. Photo: Catherine Ivill
4. Ciaran Clark - 6.78
Ranked as Newcastle’s most consistent defender this season. Llorente’s rating was higher but was hard to make a case given he's played just 81 minutes of football so far since his summer switch from Real Sociedad. WhoScored rating: 6.78. Photo: ALEX PANTLING
5. Stuart Dallas - 6.86
Dallas has played most of the season at right-back but lining up at left-back is something he has done many times under Marcelo Bielsa. WhoScored rating: 6.86. Photo: Michael Regan
6. Kalvin Phillips - 7.06
Phillips is the man who makes it tick for Leeds in midfield. Like his teammate Cooper, his rating is only bettered by Bamford. WhoScored rating: 7.06. Photo: Alex Pantling