Leeds could have put pressure on both fifth-bottom Everton and especially fourth-bottom Burnley with a positive result in Wednesday night's home clash against Chelsea but the Whites fell to a 3-0 defeat as Dan James was sent off.
The reverse left United below the dreaded dotted line, level on points with fourth-bottom Burnley but having played a game more and with a far worse goal difference.
Fifth-bottom Everton had to settle for a goalless draw at already-relegated Watford the same night but Frank Lampard's Toffees are now two points ahead of Leeds and with an additional game left, plus a far better goal difference.
Fifteenth-placed Southampton are now the only other team who could mathematically go down to join Watford and Norwich City who have already been consigned to the drop.
However, the Saints would need a miracle set of results considering that they are six points ahead of Leeds and also have a far better goal difference.
The betting markets once again changed after Wednesday night's action and this is where Leeds, Everton and Burnley and currently predicted to finish and how each side's chances of staying up are rated based on the latest odds for relegation.
We have also looked at who is predicted to win the league and qualify for the various European slots based on the current betting market ahead of this weekend's games.